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Tuesday, July 12, 2011

UTI - Nitrofurantoin: the Super Drug

While searching for the side effects of a “super-drug” antibiotic, here prescribed  for recurring UTI, it was necessary to define Eschrichia coli, Staphylococcus and MRSA; UTI info is also included. The "super drug" has violent side-effects and weakens the immune system which allows recurring infections.

Interesting that MRSA is strains of antibiotic-resistant bacteria. That’s right, mutated germs that were/are [smart (their word, not mine)] strong enough to negate beta-lactam antibiotics. [The beta-lactam ring is part of the structure of several antibiotic families, the principal ones being the penicillins, cephalosporins, carbapenems, and monobactams, which are called beta-lactam antibiotics. These antibiotics work by inhibiting bacterial cell wall synthesis.]

See:; March 22, 2011, Garlic-Better than Penicillin and June 6, 2011 E-coli and Garlic

Garlic obliterates bacteria. Synthesis (separation, production) is not an option. There are no MRSA mutations. That’s all I'll say for now. The unedited information about Escherichia coli; Staphylococcus aureus; MRSA; UTI; super-drug antibiotic Nitrofurantoin is as follows:

Probably the most common bacterium is Escherichia coli, commonly known as E-coli. It can cause gastroenteritis, haemorrhagic colitis or urinary and genital tract infections. Its resistance is very high and getting worse. [Town Crier's commentary: It's worse because conventional antibiotics attempt to stop bacteria reproduction. With each mutated variant comes another (ineffictive) super-antibiotic that perpetuates the cycle of infection and is equally or more detrimental to the liver and kidneys than the previous.]
Staphylococcus aureus, commonly known as Golden Staph because of its colour on a laboratory plate, is normally harmless. Carried on our skin it can, sometimes, cause minor infections in wounds or create boils.

MRSA (Methicillin-resistant Staphylococcus aureus) MRSA is, by definition, any strain of Staphylococcus aureus that has developed resistance to beta-lactam antibiotics which include the penicillins (methicillin, dicloxacillin, nafcillin, oxacillin, etc.) and the cephalosporins. MRSA is especially troublesome in hospitals and nursing homes where patients with open wounds, invasive devices and weakened immune systems are at greater risk of infection than the general public.

What is a urinary tract infection (UTI)?
The urinary tract is comprised of the kidneys, ureters, bladder, and urethra. A urinary tract infection (UTI) is an infection caused by pathogenic organisms (for example, bacteria, fungi, or parasites) in any of the structures that comprise the urinary tract. However, this is the broad definition of urinary tract infections; many authors prefer to use more specific terms that localize the urinary tract infection to the major structural segment involved such as urethritis (urethral infection), cystitis (bladder infection), ureter infection, and pyelonephritis (kidney infection).

UTIs are more common in women than men, leading to approximately 8.3 million doctor visits per year. UTIs can cause problems that range from dysuria (pain and/or burning when urinating) to organ damage and even death. The kidneys are the active organs that, during their average production of about 1.5 quarts of urine per day, function to help keep electrolytes and fluids (for example, potassium, sodium, water) in balance, assist removal of waste products (urea), and produce a hormone that aids to form red blood cells. If kidneys are injured or destroyed by infection, these vital functions can be damaged or lost.

What causes UTI?
The most common causes of UTI infections (about 80%) are Escherichia coli bacterial strains that usually inhabit the colon. In the U.S., most infections are due to Gram-negative bacteria with E. coli causing the majority of infections.

Classification: Urinary germicide

Action/Kinetics: Interferes with bacterial carbohydrate metabolism by inhibiting acetyl coenzyme A; also interferes with bacterial cell wall synthesis. Bacteriostatic at low concentrations and bactericidal at high concentrations. Tablets are readily absorbed from the GI tract; bioavailability is increased by food. t 1/2: 20 min (60 min in anephric clients).

Urine levels: 50-250 mcg/mL. If the C CR is less than 40 mL/min, urine antibacterial levels are inadequate, with the subsequent higher blood levels increasing the possibility of toxicity. Antibacterial activity is best in an acid urine. From 30% to 50% excreted unchanged in the urine. Nitrofurantoin macrocrystals (Macrodantin) are available; this preparation maintains effectiveness while decreasing GI distress.

Uses: UTIs due to susceptible strains of Escherichia coli, Staphylococcus aureus.

Contraindications: Anuria, oliguria, and clients with impaired renal function (C CR below 40 mL/min); pregnant women, especially near term; infants less than 1 month of age; and lactation.

Special Concerns: Use with extreme caution in anemia, diabetes, electrolyte imbalance, avitaminosis B, or a debilitating disease. Safety during lactation has not been established.

Side Effects: Nitrofurantoin is a potentially toxic drug with many side effects. GI: N&V, anorexia, diarrhea, abdominal pain, parotitis, pancreatitis. CNS: Headache, dizziness, vertigo, drowsiness, nystagmus, confusion, depression, euphoria, psychotic reactions (rare). Hematologic: Leukopenia, thrombocytopenia, eosinophilia, megaloblastic anemia, agranulocytosis granulocytopenia, hemolytic anemia (especially in clients with G6PD deficiency). Allergic: Drug fever, skin rashes, pruritus, urticaria, angioedema, exfoliative dermatitis, erythema multiforme (rarely, Stevens-Johnson syndrome), anaphylaxis arthralgia, myalgia, chills, sialadenitis, asthma symptoms in susceptible clients; maculopapular, erythematous, or eczematous eruption. Pulmonary: Sudden onset of dyspnea, cough, chest pain, fever and chills; pulmonary infiltration with consolidation or pleural effusion on x-ray, elevated ESR, eosinophilia. After subacute or chronic use: dyspnea, nonproductive cough, malaise, interstitial pneumonitis. Permanent impairment of pulmonary function with chronic therapy. A lupus-like syndrome associated with pulmonary reactions. Hepatic: Hepatitis, cholestatic jaundice, chronic active hepatitis, hepatic necrosis (rare). CV: Benign intracranial hypertension, changes in ECG, collapse, cyanosis. Miscellaneous: Peripheral neuropathy, asthenia, alopecia, superinfections of the GU tract, muscle pain.

Properly prepared anti microbial garlic products in powder and liquid form have been scientifically proven to kill MRSA in human clinical studies. And unlike antibiotic drugs that weaken your immune system, garlic actually boosts your immune system, providing powerful added benefits over the antibiotic drugs.

The TONIC Nutritional Garlic Supplement is made from the original centuries-old recipe given to prevent colds and flu. It contains a large concentration of garlic formulated to deliver maximum protection with absolutely no unpleasantness. It is a scientifically proven panacea for the human body.

This is not medicine or medical advice. Nutritional supplements may react adversely with over-the-counter and prescription drugs. Consult a licensed health-care provider for the diagnosis and treatment of all illness and before taking any nutritional supplement.


  1. Interesting something to really consider. Thanks for keeping us abreast of the facts.

    1. Good to know you receive food for thought from our Posts - that's what we do. Please continue. Thank you for reading and responding.